Expression of transforming growth factor-? and metalloproteinases in joint capsule of frozen shoulder
- VernacularTitle:冻结肩患者关节囊组织中TGF-?和MMPs表达研究
- Author:
hong-yun, LI
;
shi-yi, CHEN
;
wei-tao, ZHAI
;
ji-wu, CHEN
- Publication Type:Journal Article
- Keywords:
frozen shoulder;
transforming growth factor-?;
metalloproteinases;
fibrosis
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of transforming growth factor (TFG)-? and matrix metalloproteinases(MMPs)in the development of frozen shoulder. Methods Twenty-four patients who underwent shoulder arthroscopy were included,and were divided into frozen shoulder group ( n =12) and control group ( n =12; n =2 for shoulder instability,n =5 for rotator cuff tear and n =5 for subacromial impingement). Joint capsule tissues at the rotator cuff interval were obtained,and the expression of TGF-?,MMP-1,MMP-2,MMP-3,MMP-9 and MMP-12 mRNA and protein was detected by Real-time PCR and Western blotting,respectively. Results The expression of TGF-? mRNA in frozen shoulder group and control group was 3.36?10 4?2.18?10 3 and 1.85?10 4?3.31?10 3,respectively,the expression of TGF-? protein was 1.55?0.33 and 1.13?0.21,respectively,and there were significant differences between these two groups ( P
