Relationship between neuronal ?4?2 nicotinic acetylcholine receptor and neurological diseases
- VernacularTitle:神经元烟碱?4?2亚型受体与神经系统疾病的关系
- Author:
hui-zhen, NIE
;
wei, LI
;
rui-li, NIE
;
ming, YIN
- Publication Type:Journal Article
- Keywords:
neuronal nicotinic acetylcholine;
?4?2 subtype;
neurological diseases
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Neuronal?_4?_2 nicotinic acetylcholine receptors(nAChRs) are the most widespread subtypes in central nervous system.?_4?_2 nAChRs mainly exist in procerebrum,parietal lobe cortex,temporal lobe cortex,hippocampus,basal ganglion and cerebellum.Researches on gene knock-out mice have demonstrated that?_4?_2 receptors participate in the development,aging,neuron survival,pain,and learning and memory,and are also involved in gamma-aminobutyric acid release and dopaminergic function.Studies have disclosed that?_4?_2 nAChRs relate to the development of variety of neurological diseases,including pain,Alzheimer's disease and Parkinson's disease.
