Effects of Pulmicort Respules on airway resisitance and airway remodeling in rats with asthma
- VernacularTitle:普米克令舒对哮喘大鼠气道阻力及气道重构的影响
- Author:
tie-feng, ZHANG
;
qing-yu, XIU
;
yu, WANG
;
jing, SUN
;
yong-qing, YANG
- Publication Type:Journal Article
- Keywords:
allergic asthma;
airway resistance;
airway remodeling;
glucocorticoid
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Pulmicort Respules on the airway resistance and airway remodeling in rats with allergic asthma. Methods Thirty-two SD rats were randomly divided into blank control group,asthma model group,Pulmicort Respules group and normal saline control group,with 8 rats in each group.On the 14th day of allergization,rats were challenged by ovalbumin inhalation and were treated correspondingly.On the 28th day,airway resistance was determined,HE staining was conducted in lung tissues of each group,and airway remodeling related parameters were also measured. Results The airway resistance of Pulmicort Respules group was significant lower than that of blank control group,asthma model group and normal saline control group(P
