Protein-protein interactions and their network analysis in bioinformatics
- VernacularTitle:蛋白质相互作用及互作网络的生物信息学分析
- Author:
chao, XIE
;
jin, GAO
;
yun-sheng, YUAN
;
yan, YU
- Publication Type:Journal Article
- Keywords:
protein-protein interactions;
protein-protein interactions networks;
bioinformatics
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The ultimate goal of post-genome research is to understand a complete set of proteins in a living organism for their expression pattern and biological function,which is called proteomics.One of the major challenges in proteome research is to study the protein-protein interactions,and the emerging bioinformatics approaches present us tremendous advantages when dealing with protein interaction networking and data analysis.Useful bioinformatics tools include protein-protein interaction network mapping,topology of the network,structure of the module and comparison of the network.The technology advancement in this field brings further understandings to the structure and function of cells at the proteome level,which may eventually lead to the discovery of new drug targets and design methods.This paper attempts to review the current researches on protein-protein interaction with an emphasis on bioinformatics intervention,and also summarizes some widely used methods for network analysis.
