Vascular effect of hydroxyl-safflor yellow A and underlying mechanism
- VernacularTitle:羟基红花黄色素A的血管作用及其机制研究
- Author:
lin, ZHANG
;
guo-shun, SHEN
;
jing-nian, ZHANG
;
pie-he, NIE
;
jian-ming, ZHI
- Publication Type:Journal Article
- Keywords:
hydroxyl-safflor yellow A;
vasocontraction;
ryanodine receptor;
1,4,5-trisphophate receptor
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the vascular effect of hydroxyl-safflor yellow A(HSYA) on rat thoracic aorta and its underlying mechanism. Methods The tension of isolated thoracic aorta rings of rats perfused with different concentrations of HSYA(1?10-6-1?10-4 mol/L) was measured using organ bath technique.The effects of HSYA on the vasocontraction induced by cumulative phenylephrine(PE)(1?10-6-1?10-4 mol/L),KCl(6?10-2 mol/L) and CaCl2(1?10-5-3?10-3 mol/L) were recorded respectively. Results HSYAcaused a concentration-dependent anti-contraction effects by KCl or PE in endothelium-intact and endothelium-denuded aortic rings.HSYA inhibited the CaCl2-induced contraction and downward shifted concentration-response curve of aortic rings.HSYA+HP resulted in more significant anti-contraction effect than single use of HSYA(P0.05).There were significant differences in anti-contraction effect between HSYA+RR and RR or HSYA(P
