Expression of osteopontin in oral mucosal epithelium in patients with oral lichen planus
- VernacularTitle:口腔扁平苔藓患者黏膜上皮细胞骨桥蛋白的表达
- Author:
ben-juan, WEI
;
yi-fei, ZHAO
;
qun, LU
;
zeng-tong, ZHOU
- Publication Type:Journal Article
- Keywords:
oral lichen planus;
osteopontin;
immunohistochemistry
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of osteopontin (OPN) in mucosal epithelium of oral local lesion in patients with oral lichen planus(OLP). Methods Forty patients with pathologically-confirmed OLP (erosive OLP,n=15; reticular OLP,n=25) were investigated,among whom 17 were complicated with mild dysplasia. Mucosal epithelium of oral local lesion was examined for the expression of OPN by immunohistochemical method. Forty healthy subjects were served as normal controls. Results The positive expression rates of OPN were 65.4% and 82.4%,respectively in patients with OLP and those complicated with mild dysplasia,and both were significantly higher than that in normal controls (10.0%) (P0.05),while both were significantly higher than that in normal controls (P
