Research on tumor suppressor gene FHIT
- VernacularTitle:抑癌基因FHIT的研究
- Author:
yang-hua, XIA
;
jian-kang, SHEN
- Publication Type:Journal Article
- Keywords:
fragile histidine triad gene;
tumor suppressor gene;
therapy
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Fragile histidine triad(FHIT) gene is a tumor suppressor gene that locates on chromosome 3p14.2.FHIT can induce cell apoptosis and inhibit cell growth by activating caspase,inhibiting PI3K-Akt-survivin signal pathway and phosphorylation of I?B-?,and binding with microtube.The inactivation of FHIT is closely related with carcinogenesis.The advances in research on the structure,biological function,relationship between inactivation and carcinogenesis,and gene therapy of FHIT are reviewed in this paper.
