Effects of interleukin-1? on discharge of neurons in paraventricular nuclei of rat hypothalamus
- VernacularTitle:IL-1?对大鼠下丘脑室旁核神经元放电活动的影响
- Author:
yang, LV
;
rong, XU
;
bao-yu, LIU
- Publication Type:Journal Article
- Keywords:
paraventricular nucleus;
interleukin-1;
AT1 receptor;
neuron discharge
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of interleukin-1 ?(IL-1?) on spontaneous electrical activity of neurons in paravenrticular nuclei,and discuss the possible mechanism.MethodsExtracellular recording technique was employed to observe the effects of IL-1? on spontaneous electrical activity of neurons in paravenricular nuclei in rat hypothalamic slices,and the influence of losartan on the electrical activity induced by IL-1? was examined.ResultsAfter exposure to IL-1?(1?10-7 mol/L),the discharge frequency was significantly increased in 46 of the 59 discharge units(78%) of neurons(P
