Expression and significance of HIF-1? and CXCR4 protein in tissues of breast cancer
- VernacularTitle:HIF-1?和CXCR4蛋白在乳腺癌组织中的表达及意义
- Author:
jian-hai, ZHANG
;
jun-feng, WANG
;
xiao-yan, TANG
;
sheng-long, QIU
- Publication Type:Journal Article
- Keywords:
hyposia-inducible factor-1?;
chemokine receptor 4;
breast cancer;
immunohistochemistry
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of hypoxia-inducible factor-1?(HIF-1?) and chemokine receptor 4(CXCR4) protein in tissues of breast cancer and its association with clinicopathological features.MethodsThe expression of HIF-1? and CXCR4 protein in 60 breast cancer,30 breast fibroadenoma and 20 normal breast samples were detected by immunohistochemistry,and the relationship between the expression of HIF-1? and CXCR4 protein in the tissues of breast cancer and its association with clinicopathological factors were analysed.ResultsThere was no positive expression of HIF-1? and CXCR4 protein in normal breast tissues.The positive expression rates of HIF-1? protein in tissues of breast cancer and breast fibroadenoma were 65.0% and 26.7%,respectively(P
