Expression and significance of SEL1L and p63 protein in esophageal squamous cell carcinoma and precarcinomacous lesion
- VernacularTitle:SEL1L和p63蛋白在食管鳞状细胞癌及癌前病变中的表达
- Author:
lin, YUAN
;
jia-wei, CHEN
;
hong-hui, HU
- Publication Type:Journal Article
- Keywords:
esophagus;
squamous cell carcinoma;
intraepithelial neoplasia;
SELl L protein;
p63 protein
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of SEL1L and p63 protein in esophageal squamous cell carcinoma and precarcinomacous lesion.Methods Immunohistochemical staining(EnVision method)was employed to detect the expression of SEL1L and p63 protein in 60 samples of esophageal squamous cell carcinoma,32 samples of high grade esophageal intraepithelial neoplasia,13 samples of low grade esophageal intraepithelial neoplasia and 33 samples of normal esophageal mucosa.Results The positive rate of SEL1L protein expression was 61.5%in low grade intraepithelia neoplasia,90.6%in high grade intraepithelial neoplasia and 96.7%in esophageal squamous cell carcinoma,significantly higher than that in normal esophageal mucosa(6.1%)(P0.05).Conclusion Both the expression of SEL1L and p63 protein increases steadily in the progression of esophageal squamous cell carcinoma,which indicates that the two genes may play a role and cooperate with each other in the carcinogenesis.
