Effect of high glucose on expression of MIP-2 and MCP-1 in macrophages cultured in vitro
- VernacularTitle:高糖对体外培养巨噬细胞MIP-2和MCP-1表达的影响
- Author:
chuan, GU
;
yong, FANG
;
tao, NI
;
wei-rong, YU
;
peng, XU
;
zhu-ying, GUO
- Publication Type:Journal Article
- Keywords:
high glucose;
chemokine;
macrophage inflammatory protein-2;
monocyte chemoattractant protein-1;
macrophage
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).The protein and mRNA expression of MIP-2 in high glucose group significantly increased after culture for 4 h,and guadually decreased then.The protein and mRNA expression of MCP-1 began to increase significantly after culture for 8 h,reached peak at 12 h,and slightly decreased after culture for 24 and 48 h. Conclusion High glucose promotes the protein and mRNA expression of MIP-2 and MCP-1 from mouse peritoneal macrophages cultured in vitro,which indicates that high glucose may delay the wound healing by increasing the expression of chemokines in diabetic mice.
