Micro-CT observation on blood vessels in tibial metaphysis of ovariectomized mice
- VernacularTitle:卵巢切除小鼠胫骨干骺端血管的显微CT观察
- Author:
wen-ge, DING
;
li-yang, DAI
;
lei-sheng, JIANG
- Publication Type:Journal Article
- Keywords:
ovariectomy;
osteoporosis;
blood vessel;
micro-CT;
bone mineral density;
biomechanical property
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the distribution of blood vessels in tibial metaphysis in ovariectomized and control mice by micro-CT(?CT),and investigate the relationship between bone regional blood supply and osteoporosis. MethodsForty mice were randomly divided into ovariectomy group(n=20) and control group(n=20).Four weeks after operation,?CT analysis was conducted to observe the bone blood vessel distribution after silicone rubber perfusion,and bone mineral density measurement,?CT bone microarchitecture analysis and biomechanical test were performed. Results Bone mineral density,bone microarchitecture in ?CT analysis,biomechanical properties and bone blood vessel distribution in ?CT analysis of ovariectomy group were significantly lower than those of control group(P
