Value of soluble epithelial cadherin in differential diagnosis of pleural effusion
- VernacularTitle:可溶性上皮型钙黏蛋白的检测在胸腔积液鉴别诊断中的意义
- Author:
ling, ZHOU
;
yi, XIANG
;
guo-chao, SHI
;
huan-ying, WAN
- Publication Type:Journal Article
- Keywords:
soluble epithelial cadherin;
pleural effusion;
tumor marker;
differential diagnosis
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of soluble epithelial cadherin(sE-cad)in the differential diagnosis of pleural effusion. Methods Patients were divided into malignant pleural effusion group,infective pleural effusion group and transudation group.sE-cad in pleural fluids obtained during the first thoracocentesis was measured by enzyme-linked immunosorbent assay(ELISA).The concentration of sE-cad in all kinds of pleural effusions was compared.The cut-off value of sE-cad for the differential diagnosis of benign and malignant pleural effusion was determined by ROC curve.The diagnostic value of sE-cad was also compared with common tumor markers such as CEA,CA199,CA125 and NSE.Results The concentration of sE-cad was significant higher in the malignant pleural effusion than in the benign pleural effusion[(38.38?4.15)ng/mL vs(14.17?0.80)ng/mL,P
