Design and validation of bone marrow histological scoring system for myelodysplastic syndrome
- VernacularTitle:骨髓增生异常综合征骨髓活检评分体系的建立及其临床意义
- Author:
mei, ZHANG
;
xin-xu, DU
;
xu-cheng, JIANG
- Publication Type:Journal Article
- Keywords:
myelodysplastic syndrome;
bone marrow biopsy;
scoring system;
early leukemia
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To design a bone marrow histological scoring system for myelodysplastic syndrome(MDS) in order to provide an objective evaluation of clinical diagnosis,disease development and outcome prediction. Methods HE and Gomori staining were used to observe the morphological alterations in 149 bone marrow biopsies.Immunohistochemical staining for MPO,CD235,F8,CD42b,CD61 and CD34 was performed.The scores of distinct morphological changes of MDS were valued. Results The bone marrow histological scoring system for MDS was established and validated.The scoring system comprised 8 distinct histological features of MDS in bone marrow biopsy.When the score was ≥5,there was significant difference between normal bone marrow biopsy and bone marrow biopsy with MDS(P
