Expression of ER? and PR in ectopic and eutopic endometrium of adenomyosis treated by mifepristone in different menstrual cycles
- VernacularTitle:米非司酮对不同月经周期异位和在位子宫内膜雌激素受体?和孕激素受体表达的影响
- Author:
lei, CAI
;
lu, QU
;
duan-duan, LA
- Publication Type:Journal Article
- Keywords:
adenomyosis;
endometrium;
estrogen receptor;
progesterone receptor;
mifepristone
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of mifepristone on the expression of estrogen receptor(ER)? and progesterone receptor(PR) in the endometrium of patients with adenomyosis in different menstrual cycles. Methods Forty-seven patients with adenomyosis and 15 normal subjects were divided into 3 groups: mifepristone group(n=24),non-drug group(n=23) and control group(n=15).The expression of ER? and PR in eutopic,ectopic and normal endometrium in proliferative phase and secretory phase were detected by immunohistochemistry. Results In non-drug group,the expression of ER? and PR in ectopic endometrial glandular and stromal cells was significantly lower than that in eutopic and normal endometrium(P0.05).The expression of ER? and PR in both ectopic and eutopic endometrial glandular and stromal cells in mifepristone group was lower than that in the non-drug group(P
