Effects of ulinastatin on voulme of blood infusion and fibrolysis in neohepatic phase in liver transplantation
- VernacularTitle:乌司他丁对肝移植术输血量和新肝再灌注后纤溶活性的影响
- Author:
ying, WANG
;
zhi-jun, LU
;
bu-wei, YU
- Publication Type:Journal Article
- Keywords:
ulinastatin;
fibrolysis;
liver transplantation
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the roles of ulinastatin in improving coagulation function and inhibiting fibrolysis in neohepatic phase in liver transplantation. Methods Forty patients who were to undergo liver transplantation were randomly divided into ulinastatin group(experiment group,n=20) and placebo group(control group,n=20).Platelet,prothrombin time(PT),activated partial thromboplastin time(APTT) and fibrinogen(Fg) were measured at induction,anhepatic phase(10 min after clamping),neohepatic phase(5 and 60 min after unclamping) and the end of operation.Coagulation index(CI) of thromboelastogram(TEG) was monitored,and the volumes of blood loss,red blood cells infusion,fresh frozen plasma infusion and cryoprecipitate infusion were recorded. Results Five min after unclamping,the number of patients with CI
