Expression of ?-catenin in keratosic dermatosis and non-melanocytic skin tumors
- VernacularTitle:?-catenin在角化性皮肤病与非黑素细胞性皮肤肿瘤中的表达
- Author:
Ai-fang, JIANG
;
Min-zhi, YIN
;
Zhi-rong, YAO
- Publication Type:Journal Article
- Keywords:
keratosic dermatosis;
non-melanocytic skin tumor;
?-catenin;
immunohistochemistry
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and significance of ?-catenin in keratosic dermatosis and non-melanocytic skin tumors. Methods ?-catenin expression was determined in 10 specimens of normal skin,10 cases of seborrheic keratosis(SK),26 cases of actinic keratosis(AK),17 cases of Bowen's disease(BD) and 35 cases of primary cutaneous squamous cell carcinoma(SCC) by immunohistochemical EnVision two-step staining method. Results The expression of ?-catenin was significantly higher in SK,AK,BD and SCC than in normal skin(P0.05),but that was significantly lower in SK and AK than in BD(P0.05). Conclusion The cytoplasmic and/or nuclear expression of ?-catenin may play a role in the progression from normal skin to keratosic dermatosis and non-melanocytic skin tumors.
