Ocular toxicity of intravitreal injection of triamcinolone acetonide in rabbit eyes
- VernacularTitle:玻璃体内注射曲安奈德对兔眼的毒性作用
- Author:
zheng-yu, SONG
;
fang, WANG
;
hui, CAO
- Publication Type:Journal Article
- Keywords:
triamcinolone acetonide;
toxicity;
retina;
electroretinogram
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the toxicity of intravitreal injection of triamcinolone acetonide on the cornea,lens,ciliary body and retina in rabbit eyes. Methods Thirty-two gray rabbits were divided into four groups(n=8).The rabbits were intravitreally injected with buffered saline solution(control group),4 mg triamcinolone acetonide(group B),1.3 mg triamcinolone acetonide(group C) and vehicle(group D).Intraocular pressure,scotopic and photopic electroretinogram examinations were performed before injection and at different time points after injection.Histologic and ultrastructural changes were observed 1 week,1 month and 3 months after injection. Results Compared with the other groups,the intraocular pressure of group B was significantly increased on day 1,week 1 and week 2 after injection(P
