Effect of valsartan on expression of receptor for advanced glycation end-products in renal tissues of diabetic rats
- VernacularTitle:缬沙坦对糖尿病大鼠肾组织糖化终末产物受体表达的影响
- Author:
rui-liang, WANG
;
hong-mei, ZHANG
;
qing, SU
- Publication Type:Journal Article
- Keywords:
valsartan;
receptor for advanced glycation end-products;
diabetic rat;
renoprotection
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of valsartan on the expression of receptors for advanced glycation end-products(RAGE) in kidneys of diabetic rats,and to explore its renoprotection mechanisms. Methods Thirty rats were divided into normal control group,diabetes control group and diabetes with valsartan group(n=10).Blood glucose,blood lipid,HbA1c,kidney to body weight ratio and 24 h urinary protein excretion were measured after 12 weeks.RAGE mRNA level was detected by real-time quantitative PCR. Results Compared with normal control group,kidney to body weight ratio,24 h urinary protein excretion and RAGE mRNA were significantly increased in diabetes control group.Compared with diabetes control group,kidney to body weight ratio,24 h urinary protein excretion and RAGE mRNA were significantly decreased in diabetes with valsartan group. Conclusion Valsartan can inhibit renal hypertrophy and decrease urinary protein excretion in diabetic rats.The renoprotective effects may be related to its inhibition on RAGE expression.
