Peroxisome proliferator activated receptor ?2 gene P12A polymorphism and type 2 diabetic nephropathy in Han population in Shanghai
- VernacularTitle:PPAR?2基因P12A多态性与上海地区汉族人群2型糖尿病肾病
- Author:
li-fang, LI
;
li-mei, LIU
;
tai-shan, ZHENG
;
nian-song, WANG
;
feng, WANG
- Publication Type:Journal Article
- Keywords:
peroxisome proliferator activated receptor?2 gene;
P12A polymorphism;
type 2 diabetes mellitus;
diabetic nephropathy
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).Frequencies of P12A12 genotype and A12 allele in DN group were significantly decreased respectively,when compared with DN-0 group(for P12A12 genotype,9.1% vs 18.1%,P=0.034,OR=0.453;for A12 allele,4.5% vs 9.0%,P=0.041,OR=0.479). Conclusion The observations suggest that P12A polymorphism of PPAR?2 gene is associated with Chinese type 2 diabetic nephropathy,and A12 allele may protect the development of diabetic nephropathy in type 2 diabetic patients of Chinese.
