Effects of intrathecal ketamine on the expression of pCREB in the spinal cord of morphine tolerant rats
- VernacularTitle:鞘内应用氯胺酮对吗啡耐受大鼠脊髓pCREB表达的影响
- Author:
jin-bian, LIU
;
wei, JIANG
- Publication Type:Journal Article
- Keywords:
ketamine;
morphine tolerance;
pCREB protein;
intrathecal
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05) in tail flick test.MPE% in group MK was always higher than group M and descended more slowly than group M,especially from the d4 to d8(P0.05). Conclusion Ketamine could block the development of morphine tolerance partly due to its inhibition effect on pCREB protein.
