Inhibitory effect of artemether on gastric and pancreatic cancer cell lines in vitro
- VernacularTitle:蒿甲醚对胃癌细胞和胰腺癌细胞的体外杀伤作用
- Author:
ru-yan, XIE
;
min-min, QIAO
;
yong-ping, ZHANG
;
mei-jie, HU
- Publication Type:Journal Article
- Keywords:
artemether;
gastric cancer;
pancreatic cancer;
cell cycle;
apoptosis;
anti-tumor effect
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibitory effect and the effect on cell proliferation and apoptosis of artemether(ART) on human gastric adenocarcinoma cell lines and pancreatic cancer cell lines in vitro. Methods The inhibitory effect of ART on human gastric cancer cell lines(SGC-7901 and MKN-45) and human pancreatic cancer cell lines(SW-1990 and BXPC-3) were detected by MTT assay,and the effect on cell cycle and apoptosis were evaluated by flow cytometry. Results It was indicated by MTT assay that the killing effect of ART on the cancer cell lines were positively correlated to time and dosage(P
