Expression of N-myc downstream regulated gene 1 in breast invasive duct carcinoma and its relationship with tumor metastasis and invasive potential
- VernacularTitle:NDRG1在乳腺浸润性导管癌中的表达及其与侵袭、转移的关系
- Author:
xiao-ming, ZUO
;
xiao-hong, YAO
- Publication Type:Journal Article
- Keywords:
breast;
invasive duct carcinoma;
metastasis;
N-myc downstream-regulated gene 1;
MMP;
TIMP
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation of expression of N-myc downstream regulated gene 1(NDRG1) with invasion of breast invasive duct carcinoma and lymph node metastasis. Methods A total of 71 specimens including 26 case of primary breast invasive duct carcinoma with lymphnode metastasis,45 case of nonmetastasis breast invasive duct carcinoma were observed.NDRG1 was detected by immunohistochemistry in formalin-fixed and paraffin-embedded sections.At the same time,the correlations of NDRG1 with E-cad,MMP2,MMP9,and TIMP2 were investigated. Results The expression of NDRG1 in breast cancer with metastasis of lymph nodes(9/26) was lower than that of non-metastasis of lymph nodes(32/45)(P
