Morphologic and functional alterations of peritoneum in uremic rats undergoing peritoneal dialysis
- VernacularTitle:尿毒症腹透对大鼠腹膜形态和功能的影响
- Author:
jiang-zi, YUAN
;
jia-qi, QIAN
;
wei, FANG
;
hui-li, DAI
- Publication Type:Journal Article
- Keywords:
peritoneal dialysis;
angiogenesis;
transport function;
ultrafiltration;
uremic,rat
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the morphological and functional alterations of peritoneum in uremic rats undergoing peritoneal dialysis(PD). Methods Thirty-five male Wistar rats were randomly divided into control group(sham operated group,n=6),uremia group(5/6 nephrectomy,n=6) and uremia with PD group(n=18).Uremia with PD group was subdivided into three subgroups according to different dialysis period(10 d,4 weeks and 8 weeks,n=6).Omenta were obtained for morphological examination,and peritoneal equilibration tests(PET) were performed to assess the transport function of peritoneal membrane. Results The number of blood vessels per high-power field in the uremia group,uremia with PD group and uremia with PD subgroups(5?3,10?5,17?5 and 19?4) were significantly increased compared with the control group(1?1),and that was much bigger in the uremia with PD group than the uremia group(P
