Metabolic profile and insulin resistance in patients with OSAS
- VernacularTitle:OSAS代谢紊乱特征及其与胰岛素抵抗的关系
- Author:
qi, SHAO
;
ying, REN
;
shan-kai, YIN
;
hong-liang, YI
- Publication Type:Journal Article
- Keywords:
obstructive sleep apnea-hypopnea syndrome;
hypoxia;
insulin resistance index;
metabolic syndrome
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
40/h) and non-severe group(n=15,AHI 5-40/h).Anthropometric measurements,fasting plasma glucose,insulin,blood fat,and CT quantitative measurement of abdominal adipose tissue were recorded. Results Insulin resistance index(HOMA-IR) in patients with OSAS was related to hypoxia independently of obesity variables.The severe group was characterized by more serious metabolic disorders and higher prevalence of metabolic syndrome than the non-severe group.OSAS was positively associated with an increased metabolic disorders risk for the severe group versus the non-severe group(OR=8.8).Using the receiver operating characteristic(ROC) curve analysis,waist circumference had the greatest areas under the ROC curves compared with body mass index and neck circumference.The results of multiple stepwise regression of lowest pulse oxygen saturation(LSpO2)during overnight sleep indicated that neck circumference followed by epworth sleepiness score(ESS) entered the equation(P
