Correlation between PAK1 gene polymorphism and prognosis of endocrine therapy for breast cancer
- VernacularTitle:PAK1基因多态性与乳腺癌内分泌治疗的关系
- Author:
ke-ji, ZHANG
;
ying-chun, XU
;
feng-chun, ZHANG
- Publication Type:Journal Article
- Keywords:
p21-actived kinase 1;
single nucleotide polymorphism;
breast cancer;
endocrine therapy
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between p21-actived kinase 1(PAK1) gene polymorphism and prognosis of endocrine therapy for breast cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism was employed to analyze the genotype of PAK1 gene rs2298793 T→C polymorphism and rs2844327 C→T polymorphism of 105 patients with breast cancer accepting endocrine therapy. Prognostic factors such as age, state of menses, magnitude of tumor, pathological type, condition of operation, clinical stage, estrogen receptor, progesteron receptor, Her-2 and endocrine therapy drug were comprehensively considered, and Cox model was employed to analyze the relation of PAK1 genotype with the time-to-tumor progression (TTP). Results As to rs2298793C→T polymorphism, the TTP of CT genotype was shorter than TT genotype (P
