Effects of ganoderma lucidum triterpenoids on learning and memory function of aging mice induced by D-galactose
- VernacularTitle:灵芝三萜类化合物对衰老模型小鼠学习记忆的作用
- Author:
yue, ZHANG
;
neng-hui, HUANG
;
xiao-yi, ZHANG
;
jun, LUO
- Publication Type:Journal Article
- Keywords:
ganoderma lucidum triterpenoids;
D-galactose;
learning and memory;
total anti-oxidative capacity;
superoxide dismutase;
malondialdehyde
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effects of ganoderma lucidum triterpenoids(GLT) on learning and memory function and anti-oxidative ability of aging model mice induced by D-galactose. Methods Senile model mice were established by D-galactose hypodermic injection for 8 weeks.GLT had been administered to two therapy groups.All the mice of different groups were tested with Morris water maze.Then the mice were killed and biochemically assayed of total anti-oxidative capacity(T-AOC),superoxide dismutase(SOD) and malondialdehyde(MDA) in the brain. Results The model mice showed worse ability in learning and memory in comparison with control mice.The T-AOC activity and SOD activity in the brain decreased and the MDA content increased in model rats in comparison with control.GLT significantly improved the changes mentioned above. Conclusion GLT improved the learning and memory dysfunction in aging model mice by modulation of the anti-oxidative ability.
