Expression of MMP-9 and TIMP-1 in ectopic and eutopic endometrium of adenomyosis treated with mifepristone
- VernacularTitle:米非司酮治疗后MMP-9和TIMP-1在异位和在位子宫内膜中的表达
- Author:
lei, CAI
;
qing, YUAN
;
wen-qing, LONG
;
duan-duan, LA
- Publication Type:Journal Article
- Keywords:
adenomyosis;
endometrium;
matrix metalloproteinases;
tissue inhibitors of metalloproteinases;
mifepristone
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether the mechanism of mifepristone in treating adenomyosis is suppressing matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1(MMP-9/TIMP-1). Methods Thirty-five patients in the mifepristone treated group(19 cases of adenomyosis) and the control group(16 cases of adenomyosis,non-drug treated) underwent hysterectomy.Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium.Expression of MMP-9 and TIMP-1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques. Results The ectopic endometrium of the mifepristone treated group expressed lower level of MMP-9,higher level of TIMP-1 and lower ratio of MMP-9/TIMP-1 than the ectopic endometrium of the control group(P
