Inhibitory effect of 5-aza-2'-deoxycytidine on human gastric cancer xenografts in nude mice
- VernacularTitle:5-杂氮-2’-脱氧胞苷对人胃癌裸鼠移植瘤的抑瘤作用
- Author:
xiang-long, TIAN
;
jie, ZHONG
;
biao, LI
;
wei, HUANG
;
yi-fan, ZHANG
;
jun, WANG
;
yan-yun, GU
- Publication Type:Journal Article
- Keywords:
gastric neoplasms;
normal epithelial specific-1 gene;
methylation;
laser capture microdissection
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of 5-aza-2'-deoxycytidine(5-aza-CdR)on the normal epithelial specific-1 gene(NES1)and the growth of human gastric cancer xenografts in nude mice,and to explore the possible anti-tumor mechanisms and search for new treatment for gastric cancer.Methods Human gastric caner xenograft model in nude mice was established and treated with 5-aza-CdR.The growth of xenografts in nude mice was observed,and the status of methylation and protein expression of NES1 gene were detected by MSP and immunohistochemistry respectirely.Results After treatment with 5-aza-CdR,the growth of the xenografts in nude mice was greatly inhibited(P
