Research progress in the relationship of interferon-inducible protein-10 with ocular neovascular diseases
10.3760/cma.j.issn.2095-0160.2017.09.017
- VernacularTitle:干扰素诱导蛋白-10与新生血管性眼病关系的研究进展
- Author:
Dan, LI
- Keywords:
Interferon-inducible protein;
Chemokine;
Chemokine receptor;
Ocular neovascular diseases
- From:
Chinese Journal of Experimental Ophthalmology
2017;35(9):852-856
- CountryChina
- Language:Chinese
-
Abstract:
Interferon-inducible protein-10 (IP-10) is a member of the ELR-CXC-chemokine family,a molecule which is paid close attention to current studies.IP-10 can inhibit neovascularization and exert its function on anti-fibrosis as it binds with CXCR3,the only specific receptor to IP-10.Accumulating evidences revealed that IP-10 also involved in the pathologic process of ocular neovascular diseases.It shows that IP-10 was closely associated with subclinical chronic inflammation and involved in the development of age-related macnlar degeneration (AMD),which would be used as a clinical biomaker to make a definite diagnosis of AMD.The IP-10/CXCR3 signal,expressed on the choroidal endothelial cells,had the ability of suppressing choroidal neovascularization.Moreover,the over expression of IP-10 in the lesions of AMD may be attributed to the induction efficacy of promoting anti-angiogenic factor expression,such as IP-10 by vascular endothelial growth factor.IP-10 had an important role in the pathogenic process of diabetic retinopathy (DR) and might be used as a new indicator to evaluate the severity and prognosis of DR.And IP-10 may have the ability to suppress proliferative DR by interrupting formation of new vessels and promoting fibrosis of new vessels.Experimental study showed that IP-10 can reduce corneal neovascularization by down-regulating the expression of proangiogenic cytokines indirectly and suppressing the migration of vascular endothelial cells and tubegenesis directly.IP-10 is involved in the development of retinopathy of prematurity and polypoidal choroidal vasculopathy.Given its unique biological characteristics,IP-10 is expected to be a molecular target to inhibit neovascularization in treatment for ocular neovascular diseases.This article reviews the recent progress in the studies on relationship between IP-10 and several common neovascular eye diseases.
