Expression of CDK4 and cyclin D1 proteins in gastric carcinoma
- VernacularTitle:CDK4和cyclin D1蛋白在胃癌组织中的表达
- Author:
juan, LI
;
ping-ping, WU
;
xu-cheng, JIANG
;
zhao-wen, YAN
;
jian-min, TANG
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
cyclin dependent kinase 4;
cyclin D1;
immunohistochemistry
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of CDK4 and cyclin D1 in gastric carcinoma,and to discuss their correlation with WHO histological classification,TNM stages and lymph node metastasis.Methods Forty paraffin wax specimens from patients with gastric carcinoma were collected and expression of CDK4 and cyclin D1 proteins were detected by immunohistochemistry.Results Immunohistochemistry demonstrated that the positive rates for CDK4 and cyclin D1 protein were 65% and 55%,respectively.There was positive correlation between CDK4 and cyclin D1 proteins(P0.05).Conclusion CDK4 and cyclin D1 proteins are frequently overexpressed in gastric carcinoma and there is a positive relationship between the two proteins,which may be involved in the development of gastric carcinoma.
