Expression of TIMP-2 in peripheral blood lymphocytes in patients with chronic obstructive pulmonary diseases
- VernacularTitle:慢性阻塞性肺疾病患者外周血淋巴细胞TIMP-2的表达
- Author:
zhen-ping, HU
;
yi-cheng, ZHANG
;
jun-gang, XIE
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
tissue inhibitor of metalloproteinases-2;
smoking index
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of tissue inhibitor of metalloproteinases-2(TIMP-2) in peripheral blood lymphocytes in patients with chronic obstructive pulmonary diseases(COPD) and the association of smoking and TIMP-2 mRNA. Methods The expression of TIMP-2 mRNA in peripheral blood lymphocytes was measured by reverse transcription-polymerase chain reaction(RT-PCR) in 44 patients with COPD and 42 healthy smokers.The correlation analysis was then conducted between TIMP-2 mRNA expression and smoking index. Results The expression of TIMP-2 mRNA was 0.753?0.154 and 1.170?0.196,respectively,in patients with COPD and healthy smokers(P
