Prognostic values of lactate dehydrogenase and ?_2 microglobulin levels in adult acute myeloid leukemia
- VernacularTitle:血清乳酸脱氢酶和?_2微球蛋白对急性髓细胞白血病的预后价值
- Author:
jing-jing, SHEN
;
lu, ZHONG
;
fang-yuan, CHEN
;
ren-rong, OUYANG
- Publication Type:Journal Article
- Keywords:
lactate dehydrogenase;
beta-2 microglobulin;
acute myeloid leukemia
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic values of serum lactate dehydrogenase(LDH) and beta-2 microglobulin(?2-MG) levels in patients with acute myeloid leukemia(AML). Methods The associations of serum LDH and ?2-MG levels at diagnosis,remission and relapse with treatment and prognosis in 68 patients with AML were retrospectively analysed. Results There were no difference in LDH and ?2-MG between AML subtypes patients.The level of serum LDH and ?2-MG at diagnosis and relapse were much higher than those at remission.Patients with lower level of LDH and ?2-MG got higher CR rate and longer term overall survival and disease-free survival.Patients with higher level of both LDH and ?2-MG got lower CR rate,shorter term of overall survival and disease-free survival than those with higher level of LDH or ?2-MG or those with normal level of LDH and ?2-MG. Conclusion LDH and ?2-MG is a singificant prognostic indicator for AML.While combined LDH and ?2-MG are more definite for the treatment and diagnosis.
