Bone mesenchymal stem cell transplantation for treatment of cerebral infarction in rats
- VernacularTitle:骨髓间充质干细胞移植对大鼠脑梗死的治疗作用
- Author:
yi, LI
;
chong-gong, ZHANG
;
jie, MA
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
bone mesenchymal stem cell;
transplantation;
rat
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective and repairing effects of bone mesenchymal stem cells(BMSCs) transplantation on cerebral infarction in rats and to study the different effect of transplantation at different time points. Methods Middle cerebral artery occlusion(MCAO) models were set up,and the rats were divided into a control group,a group with PBS transplantation and five groups with BMSCs transplantation 3,6,12,24 and 72 h after MCAO,respectively.The volume of infarction area and the neurological severity score(NSS) in all the groups were compared. Results Twenty-eight days after MCAO,the TTC staining indicated that the volume of infarction area in the groups with BMSCs transplantation decreased remarkably compared with the control group and the group with PBS transplantation(P
