Effect of lipo-PGE1 on proteinuria in patients with diabetic nephropathies
- VernacularTitle:前列地尔治疗糖尿病肾病蛋白尿的疗效
- Author:
yun, ZHANG
;
xue-fang, FENG
;
rong, ZHOU
;
lu, FANG
;
jie, SHEN
- Publication Type:Journal Article
- Keywords:
alprostadil;
diabetic nephropathy;
proteinuria
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effectiveness and safety of lipo-PGE1 on proteinuria in patients with diabetic nephropathy. MethodsForty-eight cases suffering from diabetic nephropathy with proteinuria exceeding 0.5 g/d and stage Ⅱ-Ⅳ of chronic kidney disease were divided into two groups.The basic treatment scheme for all the patients includes insulin and/or oral antidiabetic drugs and anti-hypertension drugs.The patients in the control group were given dipyridamole,and those in the lipo-PGE1-treatment group were managed with lipo-PGE1(alprostadil injection),10 ?g,qd?14 d.Results After the treatment,a decrease in proteinuria and increase in serum albumin were observed in the lipo-PGE1-treatment group,which was superior to the control group(P
