Thyroid-stimulating hormone receptor and its cleavage and shedding
- VernacularTitle:促甲状腺激素受体的裂解和脱落
- Author:
qin-min, GE
;
qing, SU
- Publication Type:Journal Article
- Keywords:
thyroid-stimulating hormone receptor;
cleavage;
shedding
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid-stimulating hormone receptor(TSHR)is an important autoantigen whose cleavage and shedding can induce autoimmunity.The TSHR is the main functional receptor of the thyroid.The shedding of the ? subunit plays an important role in the forming of TSAb and balancing between TSAb and TBAb.Research on the cleavage and shedding of the TSHR extracellualar domain helps to gain a deep insight into the structure and function of TSHR,illuminate the pathogenesis of autoimmune thyroid disease and find out a new therapy.The structure of TSHR,the mechanism and the significance of its cleavage and shedding are reviewed in this article.
