Effect of benazepril on expression of RAGE in renal tissues of diabetic rats
- VernacularTitle:苯那普利对糖尿病大鼠肾组织RAGE表达的影响
- Author:
rui-liang, WANG
;
hong-mei, ZHANG
;
qing, SU
- Publication Type:Journal Article
- Keywords:
benazepril;
receptor for advanced glycation end-produts;
diabetes mellitus;
diabetic nephropathy
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of benazepril on the expression of receptors for advanced glycation end-products(RAGE)in diabetic rat kidneys,and to explore its mechanisms of renal protection in diabetic rats. Methods Thirty SD rats were randomly divided into three groups(n=10 in each group): normal control group,diabetic control group and diabetic with benazepril group.Blood glucose,blood lipid,HbA1c,kidney to body weight ratio and 24 h urinary protein excretion were detected after 12 weeks.RAGE mRNA level was analyzed by quantitative RT-PCR. Results Compared with the normal control group,the blood glucose,HbA1c,triglyceride,total cholesterol and low density lipoprotein cholesterol in the diabetic control group and diabetic with benazepril group were significantly increased(P0.05).The kidney to body weight ratio,24 h urinary protein excretion and RAGE mRNA level in the diabetic with benazepril group were significantly higher than those in the normal control group(P
