Influence of Oral Antigens on Expression of Costimulatory Molecules CD80/CD86 on Surface of M?
- VernacularTitle:口服抗原对巨噬细胞共刺激分子CD80/CD86表达的影响
- Author:
Ai-min, ZHAO
;
Qi-de, LIN
- Publication Type:Journal Article
- Keywords:
oral antigen;
abortion;
pregnancy immunological tolerance;
CD80/CD86
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of oral antigens on the expression of costimulatory molecules CD80/CD86 on the surface of M and to investigate the genesis of pregnancy immunological tolerance induced by oral antigens through CD80/CD86. Methods Mice of spontaneous abortion(CBA/J?DBA/2) were divided into two groups: immune group and non-immune group.Trophoblast membrane antigen-2(TMA2)or ovum albumin(OVA) was administered orally to the mice in the immune group.Mice of normal pregnancy(CBA/J?BALB/c) were served as controls.The number of CD80/CD86 M of spleen and mesenteric lymph node(MLN) were determined by double-label FCM method. Results In the MLN,CD80 M of non-immune group was increased significantly as compared with that of the control group(P
