Chemopreventive Effect of Salvianolic Acid B on Oral Carcinogenesis
- VernacularTitle:丹酚酸B对口腔癌的化学预防作用
- Author:
ya, YANG
;
de-rong, ZOU
;
zeng-tong, ZHOU
- Publication Type:Journal Article
- Keywords:
salvianolic acid B;
oral cancer;
chemopevention;
angiogenesis
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the chemopreventive potential of salvianolic acid B against 7,12-dimethylbenz(a)anthracene(DMBA)-induced hamster buccal pouch carcinogenesis with respect to angiogenesis. Methods(Sixty) male Syrian golden hamsters were randomly divided into 4 groups(group A and B,n=20;group C and D,(n=10).) DMBA solution(0.5% in acetone) was applied topically to the right cheek pouch of male Syrian golden hamsters in group A and B,while animals in group C were painted with acetone,3 times a week for 6 weeks.Animals in group D received neither DMBA nor acetone in the first 6 weeks.Two days after the last treatment of(DMBA,) animals in group B and D received salvianolic acid B daily(10 mg/kg) by gavage,while animals in group A and C received same volume of saline,for the next 12 weeks.At the end of the experiment,animals were sacrificed and tissue samples were collected for histopathological and immunohistochemical examination. Results Salvianolic acid B significantly decreased the incidence of squamous carcinoma(P
