Role of Nuclear Factor kappa B in Neointima Formation after Balloon-Injured Rat Artery
- VernacularTitle:核转录因子NF-?B对大鼠血管球囊损伤后新生内膜形成的作用
- Author:
jun, ZHOU
;
guo-ping, LU
;
chun-fang, WU
;
zhen-yue, CHEN
- Publication Type:Journal Article
- Keywords:
nuclear factor kappa B;
neointima;
antisense oligonucleotide;
decoy oligonucleotide
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective We examined the in vivo effect of the antisense or/and decoy oligonucleotide of nuclear factor-?appa B (NF-?B) on balloon-injured smooth muscle cell proliferation and MMP-9 in the carotid artery of rats. Methods Sprague-Dawley rats underwent balloon-dilation injury of the left carotid artery. Rats were divided into 7 groups(n=18) and each group included 6 time points (6 h and 1,3,5,7,14 d)(n=3). Results The mean intima/media ratio increased significantly in sense group、scramble group and model group and reached the maximum at 7 d after rat injured carotid artery, compared with normal group, antisense group, decoy group and decoy plus antisense group(P
