Establishment of Rat Models with Alzheimer's Disease Induced by ?-Amyloid Protein and Effects of Nicotine on the Animal Models
- VernacularTitle:A?对大鼠记忆和空间定向能力的影响及尼古丁的干预作用
- Author:
yong-bo, ZHAO
;
wen-wen, LIU
;
chun-ni, GUO
- Publication Type:Journal Article
- Keywords:
?-amyloid peptide;
Alzheimer's disease;
learning and memorizing;
nicotine;
Morris water maze test
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish rat models with Alzheimer's disease(AD) induced by ?-amyloid,and to observe the effects of nicotine on learning and memorizing ability of the rats. Methods Aggregated A?1-40 was injected into the bilateral basal forebrain of the rats.Learning and memorizing ability of the rats were inspected through Morris water maze test.The effects of nicotine on learning and memorizing ability of the rats induced by ?-amyloid peptide were observed. Results The learning and memorizing ability of AD animal models injected aggregated(A?1-40) for 2 weeks decreased(P
