Expression Pattern of Tropomyosin Receptor Kinase after Focal Cerebral Ischemia in Rat
- VernacularTitle:原肌球蛋白受体激酶在脑缺血大鼠各脑区的表达特性
- Author:
lei-si, BIAN
;
zhen-guo, LIU
;
wen-an, WANG
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
neurotrophic factors;
tropomyosin receptor kinase;
immunocytochemistry
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression pattern of tropomyosin receptor kinase(Trk)after focal cerebral ischemia in rat,and to explore the relationship between ischemia and the pattern of Trk expression. Methods(The model) of focal cerebral ischemia was built by middle cerebral artery occlusion.Immunocytochemistry staining was used to observe the dynamic changes of Trk expression at different time of acute stage of ischemia,and the patterns at different regions of the striate and hippocampal were detected. Results Trk immuno-positive neurons widely expressed in the normal brain.The number of Trk immuno-positive neurons was decreased abruptly in the necrosis core of the focal cerebral of ischemia,while increased obviously in the penumbra region and the DG area after 6 h of occlusion(P
