Clinical Research of Blood CsA C2 Level Monitoring in Renal Allograft Recipients
- VernacularTitle:肾移植术后环孢菌素C2浓度监测及临床意义
- Author:
da, XU
;
xiang-hui, WANG
;
pei-jun, ZHOU
;
chen-long, CHU
- Publication Type:Journal Article
- Keywords:
cyclosporine A;
C2 concentration;
acute rejection
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To decrease the incidence of acute rejection in renal allograft recipients by monitoring of cyclosporine A (CsA) concentration at 2-hour after dosing(C2). Methods The CsA C2 and CsA trough concentration(C0) were assayed in renal allograft recipients.All patients were followed up for at least 1 year.The correlation of C0 and C2 monitoring with clinical outcomes was analyzed. Results At 1 week and 1 month post-transplantation,the incidence of acute rejection in patients with C2 in target level was 4.41% and 10.29%, respectively,but the incidence of acute rejection in patients with C2 in lower level was 42.37% and 36.20%,respectively. ConclusionBy reflecting the drug exposure of CsA more accurately,C2 monitoring is beneficial for decreasing the incidence of acute rejection after renal allograft transplantation.
