Genome-Wide Genetic Study on Central Neurocytoma by Comparative Genomic Hybridization
- VernacularTitle:中枢神经细胞瘤全基因组的比较基因组杂交分析
- Author:
xiao-lu, YIN
;
jian-shan, ZHU
- Publication Type:Journal Article
- Keywords:
central neurocytoma;
comparative genomic hybridization;
genetic alteration
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the genome-wide genetic alterations in central neurocytoma,and to study the pathogensis of central neurocytoma. Methods Comparative genomic hybridization(CGH) analysis was performed in 10 central neurocytomas. Results Chromosomal imbalances were demonstrated in 6 cases.Overrepresentation of genetic material was detected in 4 cases on Chromosome 2p and 10q,and 3 cases on Chromosome 18q. Conclusion(Genetic abnormalities) on Chromosome 2p,10q and 18q may be associated with the pathogenesis of central neurocytoma.
