Expression of Hypoxia Inducible Factor-1? in Vertebra Development of Mouse
- VernacularTitle:小鼠椎体发育中低氧诱导因子-1?的表达
- Author:
xun-bing, ZHU
;
lian-fu, DENG
- Publication Type:Journal Article
- Keywords:
hypoxia inducible factor;
vertebra;
osteogenesis;
development;
mouse
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression pattern of hypoxia inducible factor-1?(HIF-1?) in fetal vertebra development of the mouse. Methods The development of mouse fetal vertebra was observed dynamically,and the expression of HIF-1? mRNA at various stages was also detected by reverse transcription-polymerase chain reaction. Results The cartilaginous spine column began to form at E13.5.The primary ossification center was observed at E15.5,then the osteogenesis expanded and extended to both sides.HIF-1? mRNA began to express at E13.5,and more significantly at E14.5(P
