Cyclophosphamide impulsion therapy for child patients with systemic lupus erythematosus (a report of 6 cases)
- VernacularTitle:环磷酰胺冲击治疗儿童系统性红斑狼疮(附6例报告)
- Author:
ycng-bo, LI
;
xi-qiang, YANG
;
jin, SHEN
- Publication Type:Journal Article
- Keywords:
cyclophasphamide;
prednisone;
systemic lupus erythematosus
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To search for the therapeutic methods of child patients with systemic lupus erythematosus (SLE) and the effect of cyclophosphamide (CTX) for SLE.Methods The 14 child patients with SLE were divided into two groups: CTX impulsion therapy group (6 cases) and prednisone therapy group (8 cases). The paticnts in CTX group were treated by CTX 20-30mg/kg, divided into two days for intravenous drip. There was a interval of 15 days between the two course of treatment. The prodnisone (1mg/kg) were used too at the same time. The patients in prednisone group were treated by prednisone, 2mg/kg. d, per os, tolal for 8 weeks, then reduced the dose gradually.Results The 5 cases get the obvious effect and 1 casc get the effect in 8 waeks in CTX group, total offective rate is 100%. one case is complete remission, 5 cases have effect and 2 cases are not effect, total effective rate is 75% (P
