Significance of Changes of Serum B Cell Activating Factor Belonging to Tumor Necrosing Factor Family in Children with Idiopathic Thrombocytopenic Purpura
- VernacularTitle:特发性血小板减少性紫癜患儿血清B细胞激活因子变化的意义
- Author:
jun-hong, ZHANG
;
you-hua, XU
- Publication Type:Journal Article
- Keywords:
idiopathic thrombocytopenic purpura;
B cell activating factor;
pathogenesis;
child
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of the changes of serum B cell activating factor(BAFF) in children with idiopathic thrombocytopenic purpura(ITP).Methods The concentrations of BAFF were detected by ELISA in 42 children with ITP(test group) before and after treatment in the Children′s Hospital Affiliated to Chongqing Medical University from Apr.to Nov.2008,the blood platelet count(BPC) was detected also.And 40 children who were operated selectively were selected as control group.The variation of concentrations of BAFF were analyzed among children with ITP before,after treatment and control group.Moreover,the relationship between serum BAFF expression and BPC were analyzed by the Pearson test.Results The concentrations of serum BAFF were higher in children with ITP before treatment compared with that in control group [(0.943 3?0.583 5) ?g?L-1 vs(0.538 9?0.234 7) ?g?L-1,P0.05).There was negative correlation between serum BAFF expression and BPC(r=-0.305,P
