Analysis of Therapeutic Effect of Zoledronic Acid Combined with Chemotherapy in Patients with Cancer and Bone Metastases
- VernacularTitle:唑来膦酸联合化疗对恶性肿瘤骨转移的疗效分析
- Author:
yan, XI
;
jing, LIANG
;
xiao-lin, LIU
;
yan, LI
- Publication Type:Journal Article
- Keywords:
malignant cancer;
skeletal metastases;
zoledronic acid;
chemotherapy
- From:
Journal of International Oncology
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate therapeutic effect of zoledronic acid combined with chemotherapy in patients with cancer and bone metastases. Methods 60 patients with cancer and skeletal me-tastases were devided randomly into tow groups, 30 patients received zoledronic acid combined with chemotherapy, 30 patients only received chemotherapy. Cheotherapeutic program of tow groups were same. Results Response rate of bone pain relief was 83. 3% in zoledronic acid combined with chemotherapeutic group and 56.7% in chemotherapy alone group. Response rate of skeletal metastases was 53. 3% in zoledronic acid combined with chemotherapy group and 20. 0% in chemotherapy alone group. Response rate of movement capacity improvement was 73. 3% in zoledronic acid combined with chemotherapeutic group and 30. 0% in chemotherapy alone group. The therapeutic effect of zoledronic acid combined with chemotherapy group was better than that of chemotherapy alone group( P
