Concentrations of Methotrexate Elimination after High Dose Infusion and Its Influencing Factors
- VernacularTitle:大剂量甲氨蝶呤消除相血药浓度及其影响因素
- Author:
ying, HUA
;
wei-hong, ZHAO
;
xin-tian, LU
- Publication Type:Journal Article
- Keywords:
methotrexate;
acute lymphoblastic leukemia;
drug concentration;
risk factors;
child
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
1 ?mol?L-1,and it was defined as "delayed" MTX elimination.Intra-patient variability in C48 was significant(P=0.000).Risk factors that correlated with increased C48 of MTX were boys,abnormal urine routine tests within 1 week before infusions,concurrent infections within 2 weeks before infusions,and co-administration of ceftriaxone(P
