Function of Phosphatase and Tensin Homologue Deleted on Chromosome 10 in Formation and Maintenance of Neuronal Circuits in Brain
- VernacularTitle:肿瘤抑制基因第10号染色体缺失的磷酸酶和张力蛋白同源等位基因在神经元回路形成与维持中的作用
- Author:
jing, ZHAO
;
de-yuan, LI
;
yi, QU
;
de-zhi, MU
- Publication Type:Journal Article
- Keywords:
phosphatase and tensin homologue deleted on chromosome 10;
neuronal circuits;
phosphoinositide 3-kinase signaling
- From:Journal of Applied Clinical Pediatrics
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Phosphatase and tensin homologue deleted on chromosome 10(PTEN) is a tumor suppressor which can inhibit proliferation and migration and control apoptosis in a number of cell types,mainly through inhibiting the phosphoinositide 3-kinase(PI3K) signaling pathway.A number of in vitro and in vivo studies has been instrumental in uncovering a direct correlation between deregulated PTEN/PI3K signaling and changes in neuronal morphogenesis,which is likely to have profound bearings upon the pathogenesis of neurological symptoms.This review outlines recent work on the function of PTEN during the formation and maintenance of neuronal circuits in the brain.
